While many D3s will sold to a broad range of photographers, the real target market is news and sports shooters. It will make a great deal of difference in the lives many of us lead. Whether cheaply lit gyms or dimly lit rural high-school football fields, the added sensitivity will make a huge difference in quality of content and quality of images.
ISO6400 in the shots I have seen with pre-release cameras are as close to noise free as ISO200 on my D200. Noise is visible at ISO12,800, but the images are very usable. ISO25,600 is pretty much for emergencies, where overwhelmingly significant content renders the image quality unimportant.
In actual terms, the best I could do years back, was 1/125th of a second, pushing Tri-X to ISO800. A lot of good shots were lost to blur. At ISO6400 I would have been able to use 1/1000th of a second which would have been more than adequate. Using an f-4.0 200m lens, I could have stopped down to f-5.6 and gone with 1/500th which would have been ideal.
It has a mode where one can set the shutter speed and aperture and let the ISO float. Covering sports in the daytime, often part of the field is in the shadow of the stadium, making a four to five stop difference compared to the sunlit parts of the field. One would set the shutter and aperture to the ideal setting for ISO200. When the athletes run from sun to shade, the ideal setting is not changed, but the ISO rises to provide perfect exposure in the shade as well. With such a broad range of usable ISO settings, this will truly revolutionize sports shooting.
A 12MP resolution is adequate for any publication. No problem whatever to print a two page spread in a standard size newspaper or magazine. I expect that this is the optimum size for a 36x24mm sensor. Instead of continuing in the megapixel race, Nikon wisely chose to go for ultimate image quality.
There are rumors that the about to be released Canon 1Ds MkIII requires either full time or nearly full time noise reduction with its 21MP, causing detail to be smeared, giving a somewhat "plastic" look to the shots. The D3 has NO noise reduction at all on the sensor. The D3 has caused a great deal of excitement and discussion world-wide, while there seems to be little interest in the MKIII in the Canon c&. I am trying to convince myself that it would not be foolish to spend $6,000 Cdn for a camera body!